‘Certainly, which is about ideal. I hunt for a Actual physical understanding of biological programs in a base-up way. I believe you could possibly distinguish three traces of exploration in my team in the meanwhile. The first considerations chromosome framework: How does one obtain a metre-prolonged DNA polymer folded and organised in this kind of microscopic mobile? We've produced visualisation approaches that permit us to review how, such as, SMC proteins loop DNA (video on Youtube) as a way to Create up chromosomes.
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[Laughs] ‘It was definitely a great hazard! At some time, I had been perfectly informed that it could go Erroneous and that I could grow to be much less successful, but I just disregarded that. Curiosity has generally been my strongest driving pressure. And fortuitously it all labored out.’
Deposition and atomic power microscopy of personal phthalocyanine polymers in between nanofabricated electrodes
We acquire position-of-care diagnostics test of neglected tropical health conditions within just source-limited configurations, based upon Crspr/Cas9 detecting of pathogen’s DNA in overall body fluids.
Experimental period diagram of negatively supercoiled DNA measured by magnetic tweezers and fluorescence,
What distinguishes biology from chemistry is usually that these elements alongside one another make up a residing procedure. The key of reported existence, I do think, lies while in the interactions, the interaction of Individuals molecules. The big concern in regards to the origin of life is still unanswered. How did we at any time evolve from simple molecules to the exceptionally sophisticated units we see these days? We don't know. I need to work on these kinds of major, open queries.’
2011, initially in vitro measurements of transportation throughout an individual biomimetic nuclear pore intricate; growth of multiplexed magnetic tweezers for kilo-molecule experiments; and solved the mechanism of homology recognition in DNA homologous recombination
2003, demonstrated the very first biosensors made out of a carbon nanotube; fixed the composition and system of DNA fix proteins; and discovery of ceesdekker a fresh method for fabricating strong-state nanopores for DNA translocation
Incredibly cool, but that wasn’t genuinely where my curiosity lay. I needed to pioneer and I had the sensation which was no longer attainable, as the most fascinating elementary insights experienced currently been uncovered. But my discipline experienced developed several remarkable new tools to measure particular person molecules. I made a decision that I desired to implement this to biology, to have a look at it from a physical perspective.’
Screening pseudotopological and nontopological products for SMC-driven DNA loop extrusion in opposition to roadblock-traversal experiments
Many new phenomena ended up identified, and he and his study team proven a number one placement Within this industry of investigation. Dekker and his study team identified new physics of nanotubes as well as explored the feasibility of molecular electronics. In 1998, they ended up the very first to make a transistor depending on a single nanotube molecule.
Visualization of unstained DNA nanostructures with Highly developed in-concentrate transmission electron microscopy techniques
The biophysicist from Delft – who is Just about the most cited scientists in the Netherlands for years – takes his obligation to add on the clarification and popularisation of his function at the border of physics and biology exceptionally very seriously and on a regular basis appears within the media; Otherwise to look at his operate, then about the relationship concerning science and his Christian religion.